Allergy: Genetics and IgE – Immunology | Lecturio

By Adem Lewis / in , , , , , , , , , , , /

[Music] I’ve already mentioned that genetics are important in the development of allergy so let’s take a couple of minutes to look at some of the genes that have been identified polymorphisms of genes encoding pattern recognition receptors have been described in patients with allergy so have polymorphisms in the gene encoding the cytokine thymic stromal lymph oh poor eating polymorphisms of the MHC particularly HLA DQ polymorphisms and polymorphisms in the transcription factor mad three other polymorphisms that have been described are ones for the genes encoding the interleukin-2 receptor beta chain and indeed for the cytokine itself interleukin 2 as well as polymorphisms of the genes for the interleukin 33 receptor and for interleukin 33 and as these reactions get going with the dendritic cell stimulating th2 cells and with the involvement perhaps of induced regulatory t-cells trying to dampen down the allergic response if the balance goes towards the development of an allergic response the th2 cells will become dominant with the production of cytokines such as interleukin 4 interleukin 5 interleukin 13 Zener fields will be stimulated these cells will be stimulated those B cells will class switch to IgE production differentiate into plasma cells that will secrete the IgE antibody that is so characteristic of the type 1 hypersensitivity reaction this will then bind to the FC epsilon R 1 the high affinity IgE receptor and maybe you won’t be too surprised to hear that polymorphisms in that particular receptor have also been linked to the development of allergic disease and again marcelles just like th two cells have a receptor for interleukin 33 and therefore that polymorphism is acting at several different levels during the allergic response and again TS LP is influential in modulating the activity of marcelles just like it connect on dendritic cells [Music]

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