Antihistamines | Histamine receptor agonist and antagonist | Medi tutorials
05
November

By Adem Lewis / in , , , , , , , , , , , , , , , , , , /


Antihistamines: Histamines is a mediator of inflammation and
stimulant of gastric acid secretion.Antihistamines are those drugs which block the histamin receptor
and gives antihistaminergic effect…. H1 receptor agonist:
2-methyl histamin 2-pyridyl ethyl amine
H2 receptor agonist: 4,5 methyl histamine
impromide H3 receptor agonist:
alpha-methyl histamine Now, H1 receptor antagonist:
1st generation—- * Potent and powerful sedative:
Diphenhydramine Dimenhydrinate
Promethazine Hydroxyzine
Doxylamine * Potent but less sedative:
Chlorpheniramine Chlorcyclizine
* Potent but less sedative: pheniramine
phenindamine 2nd generation—-
acrivastine cetrizine, levocetrizine
loratadine, desloratadine fexofenadine H2 receptor antagonist:
Renitidine Femotidine
Nizatidine Zolentidine what are the difference between 1st generation
and 2nd generation antihistamine? 1st generation antihistamine are more sedative,
more lipid soluable, short duration of action and should not given student, driver, working
person… But 2nd generation antihistamine are less
sedative, less lipid soluable,long duration of action and should given student, driver,
working person…


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