Aspirin (ACLS Pharmacology)

By Adem Lewis / in , , , , , /

Now let’s talk about aspirin, or shortened
to ASA. Aspirin blocks the formation of thromboxane
A2, thus inhibiting the sticking together of platelets and reducing clot formation. The use of aspirin for myocardial infarctions
helps to reduce death and the probability of reinfarction and stroke. Aspirin is indicated in the presence of signs
and symptoms of acute coronary syndromes such as those who are suffering from chest pain,
chest pressure or discomfort including pain radiating into the neck, jaw or down right
or left arm. Another reason for using aspirin is when there
are ECG changes consistent with acute coronary syndromes. Examples of this would include but not be
limited to ST elevation, depression or T wave inversion. Now, before giving aspirin, be sure to ask
if a patient has a known hypersensitivity like Sampter’s Triad. This is a serious condition and can lead to
a serious reaction when giving aspirin. Now they also need to know, before giving
aspirin, if they have bleeding disorders like hemophilia or active ulcer disease or maybe
recent gastrointestinal bleeding. Be sure to ask if the patient has a severe
allergy like anaphylaxis or asthma related to aspirin as compared to a more moderate
sensitivity like sneezing or stuffiness. If the patient does not have a severe allergy
to aspirin the benefits would definitely outway the negatives. The proper dose is to administer 2 to 4 chewable
aspirin or 162-324 mg nonenteric coated aspirin as soon as possible after the onset of symptoms. Aspirin suppositories, usually a 300 mg dose,
is a safe alternative if severe nausea, vomiting, or gastrointestinal disorders are present. Remember, in order to achieve a rapid therapeutic
blood level, instruct the patient to chew the oral aspirin before swallowing.

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