Cholesterol and Alzheimer’s disease

By Adem Lewis / in , , , , , , , , , , , , , , , , , , , , , , /

million suffer from Alzheimer’s disease and the available and foreseeable treatments are disappointing at best given the absence of disease modifying treatments there’s been growing interest in effective strategies for the prevention of the disease in the first place even if we were able to just delay the onset by as little as one year we could potentially prevent more than 9 million cases over the next 40 years once cognitive functions are lost in Alzheimer’s disease patients they may be lost forever consequently prevention rather than a cure for Alzheimer’s disease appears a more realistic strategy to offset the catastrophic impact of this dementia considerable evidence now indicates that Alzheimer’s disease is primarily a vascular disorder based on a number of lines of evidence that point towards impaired circulation of blood to the brain vascular risk factors such as high cholesterol can be thought of as a ticking time bomb to Alzheimer’s disease what’s bad for the heart may be bad for the mind traditionally there have been two competing theories for the cause of Alzheimer’s the amyloid cascade model that implicates the build-up of amyloid plaques within the brain and the vascular model that argues that it’s the lack of adequate blood flow to the brain due to atherosclerosis we now realize they are not mutually exclusive and that arterial disease can set up a vicious cycle in which Athos chlorotic plaques in the arteries may contribute to Alzheimer’s plaques in the brain although what time’s portrayed is tantamount to poison cholesterol is an essential structural component of all our cells it’s why our body makes it but if there’s too much it can become a major factor contributing to various diseases including coronary artery disease stroke and neurodegenerative diseases like Alzheimer’s too much cholesterol in our blood is unanimously recognized to be a risk factor for the development of Alzheimer’s disease and cholesterol may play an active role in the progression of Alzheimer’s as well autopsy studies have found that Alzheimer’s brains have significantly more cholesterol than normal brains and it specifically appears to accumulate in the Alzheimer brain plaques but we use the thing the pool of cholesterol in the brain was separate from the pool we had in our blood but there is now growing evidence to the contrary for example LDL may be able to cross the blood-brain barrier into the brain so a high-fat diet may not only increase cholesterol levels in the blood but also the influx of cholesterol into the central nervous system in addition having high cholesterol may even damage the blood-brain barrier itself and allow for even more cholesterol to flow into the brain providing the missing link between high cholesterol and Alzheimer’s individuals with high cholesterol levels at midlife have a higher risk of going on to develop Alzheimer’s disease a cholesterol over 250 could potentially triple the odds of Alzheimer’s and now we have high tech PET scanning of the brain that can directly correlate the amount of so-called bad cholesterol in our blood with the amount of amyloid buildup in our brain you can do it right in a petri dish adding cholesterol makes makes them churn out more amyloid that makes up Alzheimer plaques whereas removing cholesterol can decrease the level of amyloid released from cells in addition amyloid degradation is less efficient clearing amyloid is less efficient in a high cholesterol environment cholesterol can then help seed the clumping of the amyloid using an electron microscope you can see the clustering of amyloid fibers on and around little micro crystals of cholesterol once in the brain cholesterol can also undergo Auto oxidation causing the formation of highly toxic free radicals so having high cholesterol levels in the blood start to increase the risk of dementia not only by inducing atherosclerosis and impairing blood flow but may directly affect the neurodegeneration within the brain and can excess dietary cholesterol could in principle contribute to the development of Alzheimer’s disease in the evidence linking high cholesterol to Alzheimer’s appears to be steadily mounting of course some of this work was paid for by drug companies hoping to capitalize on Alzheimer’s with cholesterol-lowering statin drugs ironic since statins themselves can cause cognitive impairment though rare statin side effects may include short and long term memory loss behavioral changes impaired concentration and attention and paranoia anxiety as early as five days after starting the drugs but sometimes even months later though folks should recover within a month of stomping the drugs a better strategy then may be to change the lifestyle factors that lead to the high cholesterol in the first place particularly reducing saturated fat from the diet but it’s not enough for us to just tell our individual patients systematic implementation of education campaigns promoting radical changes and cultural and societal values may be necessary to adopt Alzheimer’s defeating strategies by patients in a broader sense and such actions may provide potentially huge dividends by preventing both cardiovascular disease and dementia two of our leading causes of death you

8 thoughts on “Cholesterol and Alzheimer’s disease

  1. Be very much aware that we have out there medical doctors who work for the pharmaceutical companies and forgot why they did medecin in the first place. Lowering cholesterol is in my daily experience the sure way to get diabetes ( 46.4%) and AD. The FDA sent a warning but people and doctors are so manipulated by a well organized lies that it is difficult to over power them. Lowering cholesterol is the biggest health scam in the last thirty years.

  2. Saying Cholesterol is like saying bird. There are different types of cholesterol and different sizes of particle. The problem isn’t Cholesterol. The problem is excessive sugar and hyperinsulineymia that result in advanced glycation end products that bind to the cholesterol. Coupled with free radicals created by industrial seed oils and the ensuing systemic inflammation that damage benign LDL particles and negatively alter them. That’s the recipe for heart disease and Alzheimer’s. Not “Cholesterol “.

  3. This contradicts what Dr. Perlmutter has found. Although it is now thought that cholesterol is the repair mechanism with coronary disease and inflammation is to blame. Could this be the case with the studies you are reading? Is there any studies that deny or confirm the link to a high grain diet?

  4. Garbabge research. Total cholesterol is a garbage parameter. Hdl/triglycerode ratio is the best measure. High choleterol diets dont necessarily lead to high hdl. Eat eggs and oily fish. Cut out processed carbs. Stop snacking. Excercise. Watch your ratio improve.

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