High LDL cholesterol levels and its association with retinopathy and peripheral neuropathy
26
September

By Adem Lewis / in , , /


So hey my name is Frida Emanuelsson and I an MD
working in the department of clinical biochemistry at Rigshospitalet in Copenhagen. So we did this study to evaluate whether high
levels of LDL cholesterol are causally related to a high risk of a spectrum of peripheral vascular
diseases that is retinopathy, neuropathy, chronic kidney disease
and peripheral artery disease. We tested this in cohorts from the Copenhagen
general population. The Copenhagen city house study and the Copenhagen
general population study and we used mendelian randomization to assess causality. We also wanted to validate the results so
we did a two-sample mendelian randomization analysis where we used allele data from the
Global Epigenetics Consortium and linked that to endpoint data from UK Biobank. So just shortly if you don’t know mendelian
randomization it is an epidemiological approach where you make use of the random assortments
of alleles and meiosis to circumvent known limitations of observational trials such as
confounding and reverse causation. So what we found was that high levels of LDL
cholesterol were not closely associated with a high risk of retinopathy or neuropathy but
were closely associated with a high risk of chronic kidney disease and peripheral artery
disease. So just think that LDL lowering therapies
would not be effective in preventing retinopathy and neuropathy but would be effective in preventing
chronic kidney disease and peripheral artery disease.


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