How to use DUPIXENT® (dupilumab): A Guide for Caregivers

By Adem Lewis / in , , , , , , , , , , , , , , , , , , , , , , , , , , /

MOM: Since you’re watching this video, I
know you’ve already learned how to give an injection with your healthcare provider.
I’m just here to help guide you through your first at-home experience. When I first started giving injections, I
found syringes really intimidating. I’ve gotten better at the process since then, so I wanted
to share those steps with you today. If you haven’t yet read the Instructions
for Use located in your treatment packaging, pause the video and take a look. And if you
have any questions along the way, don’t hesitate to reach out to your healthcare provider
or the DUPIXENT MyWay hotline. They’re always there to help. MOM: Are you ready? …OK Are you ready? SON: What? MOM: Let’s show them how to properly inject
a dose of DUPIXENT. SON: Oh, sure. MOM: First, take your medication out of the
refrigerator. Never freeze your syringe. Remove the syringe by holding the middle of
the syringe body. A few things to remember: Do not use the syringe if it has been dropped
on a hard surface or is damaged. Do not pull off the needle cap or touch the
plunger rod until you are ready to inject. Do not pull back on the plunger rod at any
time. Keep DUPIXENT syringes and all medicines out
of the reach of children. If you have an unused syringe, return it to
the refrigerator in the original carton to protect it from light.
Your DUPIXENT pre-filled syringe may appear different from what you see in this video,
based on the prescribed dose. If you have questions about the dosage prescribed, please
contact your healthcare provider. OK, now it’s time to check the label to
make sure the medication and dosage are correct and the expiration date has not passed. If
it isn’t right, contact your pharmacy. SON: Looks right to me. MOM: Yup. Now look at the medicine through the Viewing
Window on the DUPIXENT syringe. The liquid inside should be clear and colorless to pale
yellow. You may see an air bubble; this is normal. Do not try to get rid of any air bubbles. Do not use the syringe if the liquid is discolored
or cloudy, or if it contains visible flakes or particles. Throw away, dispose of, the used DUPIXENT
single-dose, pre-filled syringe right away after use. If you have any questions about whether the
syringe is OK to use, please call the DUPIXENT MyWay hotline, or your healthcare provider. Lay the syringe on a flat surface and let
it naturally warm to room temperature. The recommended warming time for the 200mg syringe
is 30 minutes, and for the 300mg syringe it’s 45 minutes. Here are a few more things to remember: Do not heat the syringe.
Do not put the syringe into direct sunlight. Do not keep DUPIXENT at room temperature for
more than 14 days. Throw away any syringe that has been left at room temperature for
longer than 14 days. Do not shake the syringe.
While you wait, gather the additional necessary materials. You need one cotton ball or gauze. SON: Check. MOM: One alcohol wipe. SON: Check. MOM: And a puncture-resistant sharps disposal
container. SON: Check. MOM: If you don’t have a sharps disposal
container, call a DUPIXENT MyWay representative to request a complimentary sharps disposal
container. When you are ready to get started, wash your
hands thoroughly. Now, take your supplies to an area where you
can sit comfortably. Choose your injection site. Both the stomach
and thigh are acceptable, except for the two inches around the belly button. The outer
area of the upper arm is also an option since you are giving the injection to someone, but
not if you’re self-injecting. Be sure to choose a different site each time
you inject DUPIXENT. Do not inject through clothes.
Do not inject into skin that is tender, damaged, bruised, or scarred. OK, now clean the skin with the alcohol wipe. Do not touch the injection site again or blow
on it before the injection. Once the skin is dry, hold the DUPIXENT syringe in the middle of the syringe body with the needle pointing away from you and carefully remove the cap from the syringe. Do not use if the needle cap is missing or
not securely attached. Do not put the needle cap back on.
Do not touch the needle. Inject the medicine right away after removing the needle cap.
Pinch a fold of skin at the injection site. Pinching the skin helps the medicine go into
a fatty layer, just below the skin, and not into the muscle. Take a deep breath. Continue to pinch as you insert the needle
completely at about a 45° angle. Relax your pinch. Push the plunger down slowly and steadily
as far as it will go, until the syringe is empty. You will feel some resistance. This
is normal. Lift your thumb to release the plunger rod
until the needle is covered by the needle shield and then remove the syringe from the injection site. Lightly press a cotton ball or gauze on the
injection site if you see any blood. Do not put the needle cap back on, and do not rub
the skin after the injection. SON: Got it. MOM: You can also cover the site with a bandage. OK, now put the used DUPIXENT syringe and
cap in an FDA-cleared sharps disposal container right away after use. Do not put DUPIXENT syringes in your household trash. Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full. Do not recycle your used sharps disposal container.
And do not reuse the syringe. If you would like to practice before doing
the actual injection and you have received the DUPIXENT training kit from your doctor’s
office, you can practice the 45° injection angle with the training syringe and the angle
aid. Do not use the angle aid to administer an actual injection. Finally, always be sure to keep track of the
injection date and site. Well, now you know how to give a dose of DUPIXENT.
If you follow these steps, you’ll be a pro in no time. Feel free to rewatch this video as many times
as you’d like. And again, reach out to your healthcare provider or call the DUPIXENT MyWay
hotline if you have any questions. Well, that wasn’t so bad, was it? SON: What?

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