Real DOCTOR reacts to CELLS AT WORK! // Episode 5 // “Cedar Pollen Allergy”
28
August

By Adem Lewis / in , , , , , , , , , , , , , , , , , , , /


hello and welcome to sick notes my name’s Edie hope a junior doctor from the UK and on this channel we talk about everything about medicine in a fun way hospitals the human body what it’s like to be a doctor I’m sorry I’ve been away for a couple of weeks but I’m so pleased to be back and looking at one of our favorite shows on the channel cells at work so here is episode 5 [Music] so this episode is called cedar pollen allergies and the pollen it’s being represented by this meteor bombard in the body so in peak times when pollen is out in the atmosphere this is exactly what would be happening so all the pollen would be bombarded our skin our eyes and in our respiratory tract so if we do have an attitude for it that’s how our body gets exposed to it it’s not the best analogy because it sort of suggests that the meteor or the pollen itself is the problem which we know not to be true because only a minority of us get these allergic reactions so hay fever when exposed to the pollen so it’s all down to our immune system being inappropriately primed to deal with the pollen so the pollen is not the problem it’s the way we react to it so pretty much exactly what we just talked about maybe I should just watch the whole show they’ve reacted the pollen is much more like a meteor shower that would be bombard nobody and it also says here about the cedar pollen the allergies occur when the immune system overreact to a certain substance the tea getting spilled us a very English problem can totally relate to that [Music] didn’t happen I mean if you went outside during peak pollen time you know just a blink isn’t gonna do a lot there’s gonna unless there’s sort of a gust of wind it might help a little bit you pretty much need your eyes closed the whole time to stop your eyes being bombarded by the pollens it’s just gonna be so much in the air so little tip is to just wear sunglasses so it will reduce the amount of pollen hitting your eyes and also makes you look cool so I think it’s safe to say that a person in this episode suffers from hay fever or the medical term allergic rhinitis so allergic because it’s an inappropriate response to the immune system to something that doesn’t normally cause us harm Ryne meaning nose as in rhinoceros the animal with a horn on its nose and itis meaning inflammations allergic rhinitis clearly and most of us this wouldn’t be happening but that would be a really short episode wouldn’t it just the asteroids bombarding and then Ed credits [Music] the poor pollen he’s very harmless he’s just a lost male sex though in a protective layer trying to find a female flower to germinate but he’s just looking in all the wrong places most dougie dollar coins gone so Toni Kukoc John okay cool so we’ve seen some phagocytosis we talked about this in our very first episode this is a key part of our adaptive immune response how our body gets better at fighting infections the more it sees so when our body Fago site OSes bacteria viruses but also in this case pollen it will take parts of the material that we call antigens so these are specific parts that we can then recognize the material later on as being foreign to our body we then create antibodies that can bind to those antigens and also specific cells that can bind to those antigens so next time we see the antigen so it might be in a larger infection we’re better at fighting it there’s also a key principle behind vaccination so we give people a tiny bit of an antigen like an inert part of the bacterial virus so our body builds up an immune response to it so if we see the real thing the real nasty bacteria or virus our body is primed and can deal with it better so vaccinations are a really good thing please don’t worry about anti-vaxxers prevention is better than the cure my wall what do I say border kkeok say that so right on cue we have our memory cell so these are the cells I talked about that have been primed to attack a specific antigen from previous antigens they’ve found so they’re called memory because we’ve remembered how to fight them better the next time there are a few different types of memory cells so you know that b-cells we’ve seen in previous episodes the teenager with the gun that fires the antibodies they fire antibodies that are specific to his antigen so they’re a form of memory cell and we have the T cells T memory cells so we’ve seen the T cells before they’re the ones that coordinate the immune response so this guy looks very much like a memory T cells this is so good a way to explain allergy and this inappropriate reaction of the immune system all because the immune system has these kind of conspiracy theories that get the idea wrong about the pollen what a lovely storytelling narrative to explain allergy to cycling [Music] or the white blood cells guys that screwed on so these damage reports they’re getting from the pollen so we know that wouldn’t really happen in real life because we talked about well none of this would really happen in real life Nepal itself is inert so it wouldn’t be causing any damage on its own like see it busting through walls and things like that so it’s really just our immune systems response to the pollen that would cause the damage there’s kind of like collateral damage from its response [Music] so as predicted the B cell rocks up you know I should totally be writing these episodes now so Sony if you’re done copy striking me give me a call for the next season we can now sort a few episodes out for you as we’re reminded here the B cell is the cell that produces antibodies and any medical students watching we’ll know which antibody we’re about to see its IgE so that’s the class of antibodies that’s involved in allergic reactions so before medical school I always wondered how antibodies actually help our bodies kill bacteria and viruses because antibodies themselves are just proteins so let me show you you may recognize this bacteria this is the one we drew from our first episode so if although it’s got some muddy pawprints on it because my cat got in here so if our body was to Faygo Saito’s this bacteria it would pick out parts of it to recognize this is what we call antigens if these happen to be on the surface then we call them surface antigens and these are pretty good antigens to try and recognize because that will help us recognize the bacteria and without breaking it down so be better to kill it so once our process being kicked off we produced a b-cell that is perfectly designed to create antibodies against these surface antigens so here are our antibodies these kind of white shaped proteins and these are specifically designed to attack the surface antigens on this bacteria so here they go attaching on to the bacteria now these are kind of like hash tags they basically tell the other immune cells eat this thing destroy this bacteria is a foreign substance that’s the main way that they work but they also have another function because part of these surface antigens on the bacteria have functions so these surface antigens may help invade cells in our body it may help communicate with other bacteria things like this well the antibodies directly bind onto them and would stop them working so these kind of fairly inert proteins have a massive role to play in your immune system clearly analogy though this is not a good idea we don’t want these antibodies because it will create a huge immune response to a bunch of harmless particles I love this memory T so it’s kind of like being a junior doctor when you see something really scary for the first time you tend to sort of amp up and then you speak to a senior in their totally controlled I’ve seen it all before he’s a Baltimore but it did it Cardone it’s good out of diet Ino shika can you handle spit this is a great preparation for medical school because these are the exact cells and ever all the processes that are involved and they’re quite complex names and complex cells so it’s really nice way to remember things so we have our memory t-cells and our b-cells the ones that produce the IgE antibody these antibodies activate them ourselves and cause them ourselves to release their cell contents which is histamine this process we call degranulation that we talked about in the last episode histamine is a mediator of inflammation so it starts off the inflammatory process and also causes lots of the symptoms that we in an allergic reaction too much history this is a really important learning point in medicine in general it comes up a lot so histamine is one of the things that causes inflammation okay and how does it work well it dilates the blood vessels it makes your blood vessels wider so in the area that’s getting damaged it also makes the blood vessels more leaky so those two things mean that more blood flow goes to the area and more stuff leaks out the blood to the tissues when that needs it so all the immune cells and all the chemicals and everything that helped sort of kill infections and start the healing process will be will go to the area where you most need it so information is really important so why is it’s important to understand well it’s a key problem when we have extreme allergic reactions so called anaphylactic reactions which you may have heard of before these are potentially life-threatening doesn’t tend to happen in things like hay fever but more tends to be reactions to peanuts bee stings latex and medications that doctors give patients too and the same process is happening so we get the dilation of the blood vessels and they become and the blood vessels become more leaky all because of this histamine release and the reason why it’s so bad is it happens not just in one area but in the whole body so when our blood vessels dilate our blood pressure drops which is very dangerous and also all the tissues become swollen because all the fluid leaking out and if this happens in our throat and in our lips we can potentially block the airway and you know make it impossible to breathe and so called suffocate so that’s why anaphylactic reactions and whites are so dangerous and why it’s important for doctors to understand this process [Music] so we get our sneeze missiles they’re back it’s really clever how they build up all the things in sales at work so we’ve seen a lot of the cells and the mechanisms before this point so that Marcel’s the B cells the histamine and it gives you you know they don’t need to fully explain it you kind of get how they all work and it’s nice to see how they work in a different scenario so we’ve seen the sneezing before when we had an infection in our respiratory tract so the sneezing was to help get rid of the infection and in this circumstance we can see the histamine kind of triggers off the same thing so an allergy we get much of the same symptoms so we get a sneezing itchy eyes and running of the eyes and nose but it’s important to know that when we have infections we tend to feel generally unwell or is it allergic reactions we don’t tend to have kind of fevers and feel really fatigue things like that so the B cell and the MRSA arguing whose fault it is the B in B cell doesn’t stand for a bonehead I actually don’t know what it stands for so let me have a look so from Wikipedia B cells are named after the bursa of Fabricius which is the organ where they were first discovered which is an organ that birds have apparently didn’t know any of this a bursa is a fluid-filled sac so we have verses in our body but fabritius I hope saying that right I don’t know what that is but it’s funny how in medicine we have we say scientific about things but then when it comes to naming it’s just it could be anything random so we don’t even have this organ yet we have cells in our body named after it for every got7 was got a lot to stock anomaly the white blood cell here is exactly right there’s nothing wrong with what’s happening uh immune system is designed to have this response so it can deal with infections it’s just should never have been triggered in the first place of all the cells are kind of doing the right thing they’re just been inappropriately primed to do that for medical use I wonder what that was because it looked so artificial and that’s what it is I’m guessing this is some medication I like the fact it was delivered by the red blood cell so the person’s eat and the tablets got into the gut absorbed into bloodstream and then traveled to where it’s needed obviously it wouldn’t be actually attached to the red blood so it would just be a drug that went in the bloodstream so I’m guessing given the patient’s got this allergy that it’s something like an antihistamine what we’d call an h1 receptor antagonist what does that mean let me tell you quickly to imagine that this is a cell in our body so here is cell on the surface it has a bunch of receptors and that is how it communicates with everything one of these receptors would be the h1 receptor the histamine 1 receptor these blue cubes represent histamine in the body so these would travel and stick on to our cell and activate the cells of these HISP these histamine molecules would go on the h1 receptors so once these receptors are activated it tells the cell what it needs to do for example if this is a cell of one of the muscles in the blood vessels we know it gets them to dilate so to widen the blood vessel so that’s what the histamine would be doing so now we have some of our drug our antihistamine our h1 receptor antagonist so how do these work well they bind to the receptor but they don’t activate it that’s one antagonist mean so if they were agonists they’d bind to the receptor and fire the receptor off but because they’re antagonists they bind to the receptor that stop the receptor from receiving any of the histamine so the histamine will come into the area but can no longer bind to that receptor because the receptor has been blocked off by the drug live is it live in terminator here I’m guessing this is an antihistamine bed right okay so this is a steroid I kind of fits a little bit better because a steroid is a much more general anti-inflammatory so that kind of fits why it’s kind of destroying a lot more stuff in the area I guess steroids are powerful anti-inflammatory and have quite far-reaching effects so lots of side effects so I guess who that’s why I’ve shown it having a minigun here as well as helping things they’re great can create some of their own problems in long-term normally in allergic rhinitis so the hay fever we see here we would just use a topical spray so a steroid no spray rather than oral steroids are they we can use oral steroids if the reaction is really bad [Music] so the steroids wouldn’t actually kill your cells they’re dampened down the immune activity by stopping the cells D granulating and activating releasing their chemicals as well so that’s how they work in fact they’d actually up regulate certain cells and when people are steroids actually get more neutrophils but clearly every story benefits from a terminator with a minigun so you can’t argue with that was a massage so there we have it another fantastic episode of cells at work I love the kind of blobby cedar potted character and the the mad scientists conspiracy theorist t-cell to explain the whole process that was going on the fact it was so mad as so inappropriate which totally fits and at the end you can’t argue with the steroid Terminator I did not expect that so yeah I hope you guys enjoyed my look at this – if there’s anything that I missed or anything you want to add please leave a comment below and if you did enjoy this video leave a like and why don’t you while you’re at it subscribe as well thanks again guys for all the support you guys continue to blow me away I’ve got lots of more stuff planned and I promise I won’t leave it as long as I did up from the last video so until next time I’ll see y’all soon [Music]


100 thoughts on “Real DOCTOR reacts to CELLS AT WORK! // Episode 5 // “Cedar Pollen Allergy”

  1. I'm back! Been a busy few weeks for me, but so pleased to take another look at Cells at Work! Hope you enjoy… Anyone wondering about the hair curl I have throughout the video, it's a homage to Red Blood Cell and not a grooming malfunction 🙂

  2. If cedar pollen season happens at the same time each year… and RBC and WBC haven't seen cedar pollen before… does that mean they're both less than a year old? (I know irl RBC's and WBC's don't live to be a year old, but apparently in Cells at Work, cells dying naturally of old age is represented by the cells replacing their worn out uniform instead of having beloved characters die.)

  3. Bursa of Fabricius is involved in B cell development in birds!

    Even as a vet student, I loved the show and I thoroughly enjoy your explanations throughout the video. Looking forward to your future videos!

  4. In my grandpa's case this episode would be well played by just some harmless smell like deodorant or hair conditioner hahaha
    Love your reactions and explanations doctor!

  5. Love this series, im so glad you are reviewing it. You have a wonderful way of explaining the facts.

  6. what i don't understand is how you get allergies. i've never had pollen allergies but about two years ago, i started having seasonal allergies with pollen. maybe i just don't understand…?

  7. I had to turn on CC for a second because I thought I'd heard, "bloody paw prints." It makes so much more sense.
    Speaking of CC, have you ever considered having subtitles made for your videos? The CC gets confused when you're talking over audio.

  8. So we have a Doctor reviewing Cells at Work and some idiot at Sony thinks he cares if you copy strike him. I hope this is one of those auto-generated copy strikes as that dude should totally be fired for stupidity alone.

  9. We were taught that b cells and t cells are both produced in the bone marrow and that b cells mature in the bone marrow, thus b cells. On the other hand, t cells are named that way because they mature in the thyroid.

  10. 7:00 That would be so cool; the 2nd season did get announced last month, no date however yet… there is also a version of Cells at Work that deals with an alcoholic person (Hataraku Saibou Black), though it's a manga and has no anime adaptation.

  11. Astronomer reacts to CELLS AT WORK: that meteor impact… wasn't very accurate. Meteors either zip through the atmosphere at tens of kilometers per second (yes), in mere seconds, and make a huge mess of a cunami when impacting water, OR they slow down to freefall, and kind of just plonk into the water. But if they're just falling, they're not melting and red hot anymore, if anything, they cool down from the wind rushing by. E for effort, show.

  12. The b does not only stand for bursa fabricii but we still keep using the name b cells bacause it can be used for bone marrow as well. T cells hint to their birth place – the thymus- too. So mastcell calling him bone head was not exactly wrong!
    English is not my first language, i apologize for any mistakes.

  13. 14:20 Totally agree on the naming thing in medicine. I'm studying to be a nurse and it's crazy to hear some of the names and the stories behind them. We'll be studying the brain and the teacher will say "These are the mammillary bodies, and they're called that because the guy naming them thought they looked like breasts" (mammary is the medical word for boobs). Yeah, great to know the people naming body parts were so creative. I like to imagine that it was like someone looking at the clouds and thinking "what does that cloud look like?", except instead of clouds they were using our bones and organs.

  14. I want to give big praise to the translator who chooses the word "Bonehead" as an equivalent word of "Baka", both of which has B as a capital. In most of Japanese-English dictionary, there are only "idiot" and "fool" as a translation of "Baka".

  15. Hi Dr. Hope! Great video, thank you for your explanations!

    I do have a few questions though… So in an allergy, what happens is that the body's cells react inappropriately to something that isn't supposed to be harmless.

    However, how does incurred allergy works? For example, I used to be able to eat chicken and take Paracetamol for my fevers. Now, if I eat too much chicken, i start getting itchy bumps forming a mountain range on my fingers. If I take Paracetamol, my throat itches and my chest begins to feel heavy.

    How does this work? Would really appreciate your insight on this matter, thank you!

  16. Could those antibodies attack a fertilized egg? I know this is about allergens…but I was wondering if those antibodies/surface antigens could be the cause of women having miscarriages

    Just a theory I had

  17. When i watch it with my brother, i also taught that the for medication thing is anti hystamin. Too bad it is steroid.

  18. I honestly love this I just can need watch the entire way through and not pause because I’ve already watched it all and just hearing Ed correct things that happen later in the episode makes me like shake

  19. In nursing school, I was taught that B-cells and T-cells are so called because they mature in the bone marrow and thymus, respectively. Never heard of this bursa of whoever 😉

  20. As someone who has allergic rhinitis, this episode represented perfectly how I feel when there is pollen in the air

  21. In the scene where the cells get a damage report the pollens are causing, as well as that one cell talking about their house being destroyed, I think it is purely the case that the pollen wasn't actually doing anything but because the cells reacted and were running around, they pushed the pollens and made them fall onto the houses and such and causing damage, and the pollen gets blamed for it.

  22. this episode was so funny, I can totally relate to it. Every spring I'm like "why boby, why?! it's just pollen!"

  23. What about sinus congestion? Like in spring the air pressure rises or drops and u have a MASSIVE sinus headache because of it? That wouldn't be the same as an allergen would it?

  24. I'm firmly convinced you now do this simply to watch Cells at Work; and honestly, I'm here for it. I stan for you Dr. Hope. ♡♡♡

  25. doctor i have a question. why do we tend to be very sleepy whenever we take anti-hestamine?
    like when ever i take one, i tend to sleep most in one whole day. if ever im awake, im so disoriented.

  26. I have just discovered these videos and I'm addicted to them, now😅
    Even though I don't understand everything Dr. Hope explains, but welp, It's still enjoyable.

  27. I suffer from allergic rhinitis due to dust particles getting thru my nose. Dunno what's wrong with my immune system

  28. I can relate to that issue as well, when I spill my tea, it feels like I have committed a cardinal sin by accident..

  29. Im 13 n learning ab dis in school right now n dis helps a lot, u make it very easy to understand, thank u 😊

  30. I'm allergic to the medication Zythromax. I was prescribed it once when I was young and I remember blacking out

  31. WOW! I always thought B cells were named because they mature in the bone marrow, and T cells were named because they mature in the thymus! Super interesting.

  32. Yeah… Maybe you should, like, give the show a bit more trust. You sometimes explain something right before the show does it.

  33. Actually hay fever is a serious problem in Japan.
    After the WW2, Japanese government planted many Cedar trees at the same time. Because of that, we have "Attack of pollen" by Cedar trees from March to April every year.
    I heard about 30% of Japanese are suffering from hay fever. That's why most of us hate cedar pollen and they were described as a humble meteorite…..

  34. I had a love-hate relationship with this episode.

    I mean, you try watching this knowing you have food allergies and basically seeing the anime-style way of why you can't have nice things. ;_;

  35. u my man just got urself a new sub! can't wait to continue watching and learning with u from this anime! one of my good friends is currently in med school not sure if he likes anime or not but i think he'll appreciate how much people can learn just by watching this anime 🙂

  36. Omg when you said the comment about relating to the tea spilling, I choked on my water from laughter lol love your content on this channel so much! All your side comments in this episode were very insightful and comedic gold.

  37. Apparently something like 80% of Japanese people are allergic to cedar pollen. I lived there for 4 years and was fine at first, but steadily each year I developed worsening allergic reactions every season. I ended up getting an injection the last year I was there to help release the symptoms throughout the season.

  38. Right on cue, he calls out a commercial break that his show took, so YouTube decided “okay, sounds like a perfect idea, time for a couple of commercials!”

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