Cholesterol, or more specifically, atheromous
plaques, which are primarily made up of immune cells jammed up with cholesterol, is blocking
up your arteries, putting you at risk of heart disease. This is not a contentious issue.
It is a fact. But, where does the cholesterol come from ? Well from the blood of course.
This is why we go to war against those cholesterol carrying particles. Not so fast ! Join us
for this episode of BETTER BODY CHEMISTRY TV, as we look inside those blocked arteries
– what we find, is game changing. Better Body Chemistry TV is brought to you by Dr Sandy
– a scientist turned gremlin buster, HELPING YOU, battle sugar gremlins, heffa-lumps & other
health horribles, through BETTER BODY CHEMISTRY. Remember, small things can make a big difference
to your health. So the current story goes something like this. The more cholesterol
loaded LDL particles that are circulating in the blood, well, the higher the odds they
have of slipping into big blood vessels. Prompting a frantic mop up, by hardworking macrophages.
The marcophages work like crazy – trying to save the day. And they do, kind of. They
mop up all that cholesterol. But it is a suicidal mission. They transition from being macrophages
to foam cells. From being an active cleaner upper, to an engorged laggard, to dead beat
bunging up the works. And then as they die, they release the cholesterol they have so
diligently squirreled away. The cholesterol flood becomes another macrophages problem.
And so it goes. Initially this awful scenario plays out, deep inside the blood vessel. At
some point in time – the whole lot blows. The plaque ruptures, clumps of congealed up
cholesterol spew forth. If the clump is big enough – and it often is. It lodges in a
blood vessel. Starving that blood vessel of oxygen and YOU HAVE a problem. But let’s
go back to the beginning. We’ll start with locating the block. Here is a cross section
through a blood vessel. The blood cells flow through the hole in the middle – the lumen.
This is where we imagine the block happens. But the actual location of the problem is
not on the edge of the blood vessel. The problem is layers and layers below. It is actually
at the border between the little layer of muscles that whip the blood around and the
edge of the border that separates the blood from “the body”. Now these layers all
have fancy latin names. The muscle layer is the tunica media and the border layer is the
tunica intima. For the record, there is another layer after the muscle layer, this one is
made of fibrous tissue and fat – it’s called the tunica adventia. Here is the story
in an actual tissue sample. The black arrows show the location of the border, between the
tunica intima and the tunica media. To make it easier to see, the researchers stained
the lipids with a red dye. The point it’s not a surface problem. So what ? Well have
you “seen” what cholesterol travels in. It’s an enormous particle – made up of
fats and protein AND cholesterol. This BLOB of blobs, has to cross around thirty or more
layers of cells-cum-matrix, to arrive at that point. The “crossing” must be fast and
seamless. You’re on the border, then you’re on the other side. There is nothing in between.
Teleporting LDL particles ? Sounds a bit far fetched ! LDL particles won’t teleport.
But this is what we’re told happens in atherosclerosis. Lipoprotein particles drifting around in the
blood, going about their business of making deliveries. Specifically cholesterol deliveries,
“spontaneously” move across the blood vessel border, drifting through 30 layers.
And once there, they proceed to become damaged. Necessitating a clean up by the immune system.
Which for the record, also dig their way through 30 layers of cell. Eish ! It doesn’t make
sense. This cannot be the full story. So what is the REAL story ? Well let’s start, by
looking at what these BIG blood vessels looks like when you’re little. When you’re little,
all three layers are there. But the inner layer is skinny, really skinny 1-2 layers
thick. So LDL particles would be able to cross in a jiffy. But they don’t. All sorts of
protective layers keep them in their place. As you grow bigger, so do your blood vessels.
Specifically the intima tunica layer. By the time you get to 15, it has thickened up to
be about 10-15 layers thick. You keep growing and so does your intima tunica. So by the
time you’re 30, it’s now about 30 layers thick. Now 30 layers thick is the sweet spot.
It is thick enough to do the job of ensuring blood moves around seamlessly, but NOT too
thick that the cells at the bottom go hungry. You continue aging , so by 40, it’s 40 cells
thick, and at 50, it’s 50 cells thick. Actually I’m joking. If all is on track, the layer
should not get any thicker. Unfortunately, if you’ve got BAD body chemistry, the layer
has a tendency to expand. Now the fact that it get’s thicker is NOT in and of itself
BAD. The cells divide because they feel compelled too. The impetus for their division is fixing
damage. The trouble is, more cells now need feeding. So to keep the more cells going,
a plan must be made. And the plan, involves growing new blood vessels. But hooking up
a direct line across the thirty plus layer of cells making up the tunica intima is fraught
with difficulties. So, lines are sent from the other side – from the tunica media side.
It’s a quick an easy solution. But, a “dirty” solution. You see the cells on the border
where never designed to have blood vessels, they’re mean to be a-vascular, that is,
blood vessel free. Being avascular, they’re not by their nature, very mindful of how clean
and tidy their matrix is. So dotted around are matrix proteins such as biglycan. Now
these matrix proteins are a magnet for LDL particles. So, as these new blood vessels
come on line to feed the additional layers, blood leaks have unintended consequences.
LDL particles begin to stick. Macrophages “see” this “sticky’ situation – and
intervene. Firing ROS tazzers at the stuck LDL particles, encouraging them to move on.
The trouble is, being tazzered with a reactive oxygen species, causes serious damage to the
LDL particles. Battered and bruised, things go from bad to worse. Clean ups are required.
And before you can say, Bobs your Uncle, there is protrusion DEEP inside the blood vessel.
It protrudes into the lumen, interfering with blood flow. And at some point in time – the
whole lots blows. The plaque ruptures, clumps of congealed up cholesterol spews forth. You
know the rest of the story. And it’s this story YOU want to avoid. Which is why you’re
doing what you can to avoid cholesterol. But cholesterol wasn’t the cause of the trouble,
per se. So the war on cholesterol, although laudable, is not going to “fix” atherosclerosis.
The fix is to manage the expansion of the tunica intima. Now a good place to start,
is to rein in insulin. For tips and suggestions on how to do this, download the willpower
report, it’s free. And begin the journey today, to creating BETTER BODY CHEMISTRY and
BETTER HEALTH. Interested in discovering more ways to create better body chemistry or need
a little help getting your body chemistry on track ? Visit our website WWW BETTER BODY
CHEMISTRY dot COM, browse our library or enrol in one of our courses or programmes. The advice
is simple to follow and based on real science, not hype. Know someone who is at war with
cholesterol Share this video with them – so they KNOW THEIR ENEMY, and can fight smarter.
And if this is your first time here, be sure to subscribe to our channel, so you catch
future episodes of BETTER BODY CHEMISTRY TV. Thank you so much for watching and I will
see you next time. Remember small things can make a big difference to your health.