The Science Behind DUPIXENT® (dupilumab)
01
March

By Adem Lewis / in , , , , , , , , , , , , , , , , , , , , , , /


How It Works INDICATION DUPIXENT is a prescription medicine used to
treat people 12 years of age and older with moderate-to-severe atopic dermatitis (eczema)
that is not well controlled with prescription therapies used on the skin (topical), or who
cannot use topical therapies. DUPIXENT can be used with or without topical
corticosteroids. It is not known if DUPIXENT is safe and effective
in children with atopic dermatitis under 12 years of age. IMPORTANT SAFETY INFORMATION Do not use if you are allergic to dupilumab
or to any of the ingredients in DUPIXENT. Please see Important Safety Information throughout
video and accompanying full Prescribing Information, including Patient Information. Atopic dermatitis, the most common form of
eczema, can be caused in part by constant inflammation in your body, which can lead
to dry, flaky, itchy skin and rash on the surface of your skin. Moderate-to-severe atopic dermatitis can be
difficult to manage. Patients with atopic dermatitis can have some
skin with rash and some skin without rash. But even skin without rash may have ongoing,
underlying inflammation. This is because the immune system is overactive. The immune response in atopic dermatitis involves
two main parts: A weak skin barrier and underlying internal
inflammation. With atopic dermatitis, outside substances
such as bacteria, viruses, and allergens may enter the weak outer layer of skin more easily
than in healthy skin. As these outside substances enter the body,
a signal is sent to the immune system, causing some immune cells in the second layer of skin
to overreact. Even when these outside substances are no
longer present, this overreaction continues. Cytokines, small proteins that affect communication
between cells, are part of the inflammatory signal that can cause the symptoms that patients
with atopic dermatitis experience. DUPIXENT is a prescription medicine used to
treat people 12 years of age and older with moderate-to- severe atopic dermatitis (eczema)
that is not well controlled with prescription therapies used on the skin (topical), or who
cannot use topical therapies. DUPIXENT can be used with or without topical
corticosteroids. It is not known if DUPIXENT is safe and effective
in children with atopic dermatitis under 12 years of age. DUPIXENT works under the skin. When DUPIXENT attaches to certain immune cells,
it inhibits an inflammatory signal from these specific cells that contributes to causing
atopic dermatitis. DUPIXENT may help reduce the rash you see
and feel on your skin, and continuously manages the inflammation over time, which is a cause
of the signs and symptoms of atopic dermatitis. In two, 16-week clinical studies with DUPIXENT Nearly half of adult patients saw a 75% improvement
and some even saw a 90% improvement Almost 4 times more adult patients (37%) taking
DUPIXENT saw clear or almost clear skin as compared with those not taking DUPIXENT (10%) Adult patients experienced significant itch
reduction, some as early as 2 weeks (38% of adults taking DUPIXENT vs 11% not on DUPIXENT) DUPIXENT can cause serious side effects, including
allergic reactions (hypersensitivity), and eye problems. The most common side effects in patients with
atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness,
swelling, and itching, and cold sores in your mouth or on your lips. Please see additional Important Safety Information
throughout and accompanying full Prescribing Information, including Patient Information. The relationship between how DUPIXENT works
in your body and its clinical effects is unknown. So ask your doctor if DUPIXENT could help
heal your skin from within. Please see additional Important Safety Information
throughout and accompanying full Prescribing Information, including Patient Information.


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