By Adem Lewis / in , , , , , , , , , /


(funky jazz music) – [Narrator] The exact
mechanisms and triggers for AERD aren’t
fully understood, though research is ongoing. It appears to be an
inflammatory process which abnormally
results in activation of cells called mast cells, as well as infiltration
of the sinuses and lungs with specialized white blood
cells called eosinophils. The activation of mast cells
and eosinophil inflammation leads to overproduction
of or sensitivity to pro-inflammatory
substances like leukotrienes and prostaglandins. These substances create a very
complex web of interactions, and ultimately a
very aggressive sinus and bronchial
condition takes hold. When a patient with AERD
takes aspirin and NSAIDs, a more dramatic
surge in the release of the inflammatory
chemicals takes place. This is what causes the
many symptoms we associate with AERD, including acute
worsening of nasal congestion, runny nose, sneezing,
coughing, wheezing, shortness of breath,
asthma attacks, and sometimes skin rash
or gastrointestinal upset.


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