What is Alzheimer’s disease? – Ivan Seah Yu Jun
25
August

By Adem Lewis / in , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , /


Every four seconds, someone is diagnosed with Alzheimer’s disease. It’s the most common cause of dementia, affecting over 40 million people worldwide, and yet finding a cure is something that still eludes researchers today. Dr. Alois Alzheimer, a German psychiatrist, first described the symptoms in 1901 when he noticed that a particular hospital patient had some peculiar problems, including difficulty sleeping, disturbed memory, drastic mood changes, and increasing confusion. When the patient passed away, Alzheimer was able to do an autopsy and test his idea that perhaps her symptoms were caused by irregularities in the brain’s structure. What he found beneath the microscope were visible differences in brain tissue in the form of misfolded proteins called plaques, and neurofibrillary tangles. Those plaques and tangles work together to break down the brain’s structure. Plaques arise when another protein in the fatty membrane surrounding nerve cells gets sliced up by a particular enzyme, resulting in beta-amyloid proteins, which are sticky and have a tendency to clump together. That clumping is what forms the things we know as plaques. These clumps block signaling and, therefore, communication between cells, and also seem to trigger immune reactions that cause the destruction of disabled nerve cells. In Alzheimer’s disease, neurofibrillary tangles are built from a protein known as tau. The brain’s nerve cells contain a network of tubes that act like a highway for food molecules among other things. Usually, the tau protein ensures that these tubes are straight, allowing molecules to pass through freely. But in Alzheimer’s disease, the protein collapses into twisted strands or tangles, making the tubes disintegrate, obstructing nutrients from reaching the nerve cell and leading to cell death. The destructive pairing of plaques and tangles starts in a region called the hippocampus, which is responsible for forming memories. That’s why short-term memory loss is usually the first symptom of Alzheimer’s. The proteins then progressively invade other parts of the brain, creating unique changes that signal various stages of the disease. At the front of the brain, the proteins destroy the ability to process logical thoughts. Next, they shift to the region that controls emotions, resulting in erratic mood changes. At the top of the brain, they cause paranoia and hallucinations, and once they reach the brain’s rear, the plaques and tangles work together to erase the mind’s deepest memories. Eventually the control centers governing heart rate and breathing are overpowered as well resulting in death. The immensely destructive nature of this disease has inspired many researchers to look for a cure but currently they’re focused on slowing its progression. One temporary treatment helps reduce the break down of acetylcholine, an important chemical messenger in the brain which is decreased in Alzheimer’s patients due to the death of the nerve cells that make it. Another possible solution is a vaccine that trains the body’s immune system to attack beta-amyloid plaques before they can form clumps. But we still need to find an actual cure. Alzheimer’s disease was discovered more than a century ago, and yet still it is not well understood. Perhaps one day we’ll grasp the exact mechanisms at work behind this threat and a solution will be unearthed.


100 thoughts on “What is Alzheimer’s disease? – Ivan Seah Yu Jun

  1. Thanks for creating an amazing video to educate. This will help educate my clients.

  2. What if we found a way to strengthen the walls of the nerve cells, causing them to not collapse as much (idduno, I'm just in seventh grade, k? Plus, I'm not good with words.)

  3. My grandfather was diagnosed with this terrible disease in 2011 and forgot who he was. My grandmother knew something was going on with him and he wasn't himself 3 years before he was diagnosed. I feel really bad for my baby cousins that just turned one not that long ago and they will never know who their grandfather is. Even sometimes I have a hard time believing that he is actually my grandfather that I knew and loved so much.

  4. Its a Doctor derived disease. Your brain is over 80% Cholesterol, so if you take statin drugs and eat low fat food your brain slowly dies. Big pharma and food corporations are killing you all, unless you know the truth.

  5. It's important for those caring for a loved one with Alzheimer's to surround themselves with a strong network of support. Caregiver burnout is a very real danger, particularly when caring for someone with dementia. Free downloadable resources are available here: http://akhomehealth.com/home-care-library/alzheimers-education-treatment-modality/

  6. when I look at people forget what room they're in because of this honestly makes me sad but sometimes I laugh..

  7. Just found out my Dad has Alzheimer's disease tonight. I, of course, am not handling it well. At all. They said it will kill him, they have no cure, it will progress in time to make him worse, then told me what the diease will do to him. With my future dead father in mind, I am going to have a meltdown now.

  8. Thank you for this very helpful information. Let's hope a cure is just around the corner! Those who need assistance with Alzheimer's care can find help and resources here: http://customhomecare.net/alzheimer-and-dementia-care-program/

  9. GRAB THE NEW eBOOK "The End of Alzheimer's by Dale Bredesen"
    https://www.ebay.com/itm/The-End-of-Alzheimers-by-Dale-Bredesen-eBooks-Prevent-Reverse-Cognitive-Decline/112614680068?epid=236561651&hash=item1a385ba604%3Ag%3AAAoAAOSwSrNZ6USM&_trkparms=pageci%253Af4c35177-bb53-11e7-bd25-74dbd1809b67%257Cparentrq%253A5f7c23f215f0a9cac67044d4fffcdd99%257Ciid%253A1&redirect=mobile

  10. Bill Gates has recently committed to curing Alzheimer's. It won't be easy but it will be worth it for the humanity. Just imagine how many lives would be monumentally changed if this endeavor would succeed. Hopeful for more good guy Bill Gates.

  11. I have ADD and a sympton is short term memory but does that also mean that i am developing alzheimer? Please help me with this question (i am 15 btw so i don't think i am developing it but still)

  12. 2:46 Your Alzheimer's is so severe your brain forgets how to breathe and pump blood into your system. Nuuuu! That is so tragic. D':

  13. Alzheimer’s disease around the world may due to 7 main controllable risk factors: diabetes, high blood pressure, obesity, smoking, depression, mental inactivity or low education, and physical inactivity. For More info please visit http://www.alzdisease.com/

  14. Maybe quit giving vaccines that contain aluminum salts that far exceed the established safe levels.
    https://www.youtube.com/watch?v=oqf9HO3WN_A

  15. Ganoderma lucidum has the anti-inflammatory property by which it reduces the effects of Alzheimer's
    http://dxnganodomicz.blogspot.com/2018/01/el-ganoderma-lucidum-frente-al-alzheimer.html

  16. https://youtu.be/aTYI4xcAqcM bonita música sobre saúde
    Veja este e muitos outros vídeos do Dr. Walter Veith no Youtube. https://youtu.be/bj7WaP7Xn1M?list=PLJnhVDPdBOQzODX79IvDZcRhkLa3gKtyq < > Dr. Walter Veith Estilo de Vida Alternativo

    http://ellenwhiteaudio.org/pt/conselhos-sobre-o-regime-alimentar/ muitas informações em áudio e texto

  17. Something new I learned about Alzheimer’s is once healthy neurons stop functioning connections with other neurons are lost and eventually die. Some possible strategies to prevent Alzheimer’s is to sleep regularly because deep sleep is a form of cleansing for the body and mind. Eating healthy can also be a factor to avoid Alzheimer’s as well as not smoking cigarettes. These are commonly found to increase the risk of Alzheimer’s.

  18. we must kill Dementia/Alzheimers now. The implications are confounding/apocalyptic if we don't find a viable treatment to stop the disease now . We have a Dementia BOMB brewing in the next 25yrs which will overwhelm even successful social medicine models worldwide

  19. Why is it so hard to figure out a way to break down the plaque and detangle the nerve cells? Perhaps add more than

  20. Beta amyloid plaques are not the cause of Alzheimer's disease. They are found in healthy people and some people with the disease don't have them.

  21. wait wait wait… so theres a vacune… lol what am I doing here then, who needs cures when you can prevent it, prevent before you have to cure it, didnt you heard that one?

  22. My grandmother has that disease from 2015 and now is 2018 the doctor said that she will live only 10 years and i she has the issues that i saw in this video. It's also existing a drug against that disease that will not cure, but idk what it will do.

  23. **** everyone is busy in developing weird technological things and neglecting the medical field. There should be balance in medical and technological field. Medical field should be encouraged everywhere.

  24. One little mistake I think I picked up. At 2:43 it states the brain controls heart rate and breathing. Indeed it does control breathing however heart rate is controlled by its own pacemaker cells found in the sinoatrial and atrioventricular node within the heart.

  25. Hey! I am doing a fundraiser to raise money and end Alzheimer’s! If you could support me in this effort it was be REaLY greatly appreciated. A donation of even 1 dollar would be a huge difference. Thank you 🙂

    http://act.alz.org/goto/CaroEndsAlzheimers

  26. Its so sad if one of your parents have this azhermer watch this
    I promise you will die crying
    (The greatest love) this movie shows what siblings can do to their mother.

  27. This Life and all the parts are from our God the Creator Sustainer and The Provider.
    Therefore, our OMNIPOTENT Eternal Almighty God can restore and bring us complete healing at ANY AGE.
    I BELIEVE.

  28. If you want to relieve the symptoms of Alzheimer's or dementia disease take an eyebrow tweezers and remove the hair follicles from the patients hands, feet, and wrists. This should have an immediate effect on their well being.

  29. Here's away take that person back to the spots theve been or a person or a key word and it helps it's working on me every spot I go it brings back memories I've been alot of places when I was a boy I seen alot done alot I've always been a good person no matter what anyone said bout me I've been lied on a lot

  30. If what makes us feel alive is consciousness, is it possible that somebody who has this disease is already dead before his/her actual death (for example, I know that I'm alive because I think, otherwise I couldn't interact) in an advanced stage of Alzheimer?

  31. ALZEHEIMERS DISEASE IS A RARE DISEASE IN WHICH ONE STARTS
    FORGETTING ABOUT THINGS. HIS OR HER MEMORY POWER DECREASES DAY BY DAY. ONE
    SHOULD HAVE PROPER KNOWLEDGE ABOUT THE DISEASE THAT WHY IT HAPPEN AND HOW TO
    GET IT TREATED. MAINLY THE OLD AGE PEOPLE SUFFER WITH IT. TO KNOW MORE ABOUT
    THIS DISEASE OPEN THIS LINK https://www.planetayurveda.com/blog/herbs-ayurvedic-treatment-alzheimers-disease AND
    HAVE FULL KNOWLEDGE ABOUT THE SUFFERING SO THAT ONE CAN UNDERSTAND THEIR
    SYMPTOMS AND GET IT TREATED ON TIME

  32. I just want to quickly say this to the world ear, though i'm not good in this but i just feel very happy to say this to the world,I love my mother so much that i can do anything for her to live a healthy life and always be happy, in her early 40's she develop Alzheimer's Disease and i took her to so many doctor all they said was there is no cure but she can get medication that will support her everyday life which make me very unhappy and i wanted this cure to be permanent, till i came across this man online a Dr who work in Health Med Lab Clinic and i explain everything to him and he said he can cure my mom because their clinics deals with natural herbal medicine and they treat and cure any incurable disease, which i decided to give a try, i get the medication from them and my mom start using it as instructed within just a couple of 2 Months, my mom get her health back again and did a test which come out to be Alzheimer's free wow!! this is really genius and i want you there to also give a try and you will come back and thank me later here is their email address [email protected] They cure any incurable diseases you might be suffering from

  33. Honestly I don't really think it's all that bad, considering how many ways a person can die this seems pretty merciful. When a person has Alzheimer's they pretty much just "live" in their most vivid memories and also they aren't really aware of the fact that they are dying. The only people Alzheimer's hurt emotionally are the people close to the affected person. And honestly spending my last days reliving the most memorable parts of my life seems like a nice way to go.

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