Why Do We Get Allergies?
25
August

By Adem Lewis / in , , , , , , , , , , , , , , , , /


It’s that time of
year when tissue companies nationwide rejoice at the excessive mucus caused by allergies. If you’re one of the unlucky, you might
ask yourself why we get them anyway? Why would our immune systems react to seemingly
harmless things like pollens, dust mites, and the dander from cats and dogs? There are two proposed theories here; the
most widely accepted involves an evolutionary mechanism for expelling parasitic worms, a
frequent problem for our ancestors before the advent of modern medicine and potentially
living in a more hygienic environment. A relatively newly suggested competing theory
is that the reaction is due to how the immune system responds to a type of cell, known as
a mast cell, when it releases its chemicals of inflammation. Before we can understand the two theories,
it’s important to know how the immune system works in general when it encounters a potential
allergen. There are two ways it can deal with a foreign
pathogen- either kill it (type 1 reaction) or attempt to expel it from the body (type
2 reaction). Should you have a large pathogen, like say
a parasitic worm, the body would generally illicit the type 2, expulsion tactic. A smaller microbe, like a bacteria or virus,
will generally trigger the type 1 response. What exactly is happening when the immune
system gets stimulated? (In an attempt to avoid writing a book on
the topic, I will only touch on the parts pertaining to allergies themselves and not
the immune system as a whole.) All the cells of your immune system revolve
around a class of cells called white blood cells. One type of white blood cell is a B cell. B cells have antibodies on their surface;
known as Immunoglobulins (Ig), they are Y shaped proteins. When an allergen contacts your skin, eye,
nasal passage, mouth, airway, or in your digestive tract, it will attach to the antibody on the
B cell. The B cell will then become activated. Once activated, they will begin to multiply. Some turn into memory B cells that will recognize
the same molecule later in life and be able to more quickly mount a defense. Some turn into plasma B cells (effector cells). These make more identical antibodies that
attach to the molecule its predecessor just recognized. They’re so good at it that one effector
cell can produce about 2000 identical antibodies per second! Those antibodies will then attach to the invader
and mark it for recognition by other white blood cells that will destroy the suspicious
molecule. They do this by attaching themselves in a
process called opsonization. Different allergens will end up producing
different antibodies. In 1967, two research groups from Colorado
and Sweden identified a new type of Ig, known as IgE. This little antibody proved to be the main
force starting a cascade of events that leads to those sinister allergy symptoms. More recently, scientist have been able to
genetically engineer mice to stop making IgE. Those mice don’t get allergies. Science! In any event, once produced, IgE begins circulating
around and attaches to the receptors (Fc type I and II) on the previously mentioned mast
cell. These cells are responsible for most of the
processes involved in the symptoms you feel when suffering from allergies. When stimulated, they begin secreting a barrage
of chemicals, called degranulation. One example is the release of histamine. Histamine is important for several of our
allergic reaction symptoms- things like the constriction of your bronchioles, the dilation
of your arteries, the perception of itching, and the production of hives. It’s also responsible for many of the processes
involved with inflammation. So to sum up on the how, or at least as it’s
generally understood (there is some controversy here as we’ll get into in a moment) an allergen
enters the body, attaches to B cells; IgE is created and stimulates mast cell degranulation;
inflammation ensues and all the symptoms you feel begin causing their web of woe. The immune system stays activated until it
senses no more allergen to attack, and you’re now you’re back to normal! With the “how” covered, this bring us
back to the question of why we get allergies to things that are seemingly harmless? No one has definitively answered the question,
but everyone seems to agree that IgE is the main antibody responsible for all the immune
system reactions and the inflammation it brings. So, what in natural selection made IgE an
important trait required for our ancestor’s survival given today some consider it mostly
useless, and more than a little annoying for those with allergies? Until recently, the leading theory revolved
around parasitic worms. In 1964, scientist Bridget Ogilvie showed
that IgE was found to be in abundance in rats infected with worms. Our ancestors also had a problem with worms. They didn’t have access to modern medicine
and hygienic environments that have reduced the infection rate down to the current 20%
worldwide (with most that are infected residing in underdeveloped countries). Throughout much of history, everything from
roundworms, such as hook-worms, to flatworms, like tapeworms and liver flukes, were relatively
common. IgE and the symptoms it creates, like sneezing
coughing and diarrhea, all serve to expel those nasty little freeloaders. As Dr. David Dunne from the university of
Cambridge states, “You’ve got about an hour to react very dramatically in order to
reduce the chance of these parasites surviving… Allergy is just an unfortunate side-effect
of defense against parasitic worms.” So IgE’s ability to kick things into high
gear to quickly react to such an invader would seemingly be very handy here. What do parasitic worms have to do with allergies? The idea here is that the reason we get such
a strong reaction to certain other less threatening things that our immune system might be much
better off ignoring is that the proteins on the surface of parasitic worms are similar
to the molecules we encounter in other aspects of our lives. The B cells responsible for the immediate
immune system response react to a non-specific class of molecules. Thus, our immune system will respond to allergens
that are structurally similar to the proteins found on the surface of worms. The body then attempts to rid itself of them,
whether they’re harmful or not. The left-over response from our immune system
reacting to worms (and now similar protein molecules) is why allergies continue to torment
landscapers everywhere, or at least as far as this theory goes. While a long-standing theory and very widely
accepted in the medical world, the defense against worm’s philosophy gets somewhat
undermined when you look at studies showing IgE isn’t actually strictly necessary to
fight them off. The mice scientists have genetically engineered
to be unable to produce IgE are still able to rid themselves of the parasites. That’s not to mention the fact that people
can have these types of allergic reactions to things that have no possible biological
link to any protein found on a worm, such as reacting to the metal nickle. So even if this is a factor in why we have
allergic responses to seemingly otherwise harmless things, it can’t tell the whole
story. This brings us to the slightly newer theory
as to why we have allergies. It also involves the idea of our bodies attempting
to expel allergens, but instead of the immune system recognizing a structurally similar
protein molecule to that on parasitic worms and misinterpreting that the body has acquired
such a parasite, it is the immune system reacting to actual damage caused by that invader- namely,
the destruction of those mast cells. When mast cells begins to degranulate, the
body begins making antibodies to several of the proteins around the area affected to try
to get rid of whatever foreign agent. Should it inadvertently make an antibody to,
for instance, the proteins found on peanuts, you will then get memory B cells to fight
against peanut molecules in future. Congratulations, you now potentially have
a peanut allergy. Dr. Ruslan Medzhitov, professor of Immunobiology
at Yale University School of Medicine (and arguably the biggest promoter of this theory),
likes to think of it like how we protect our homes. If you’re not home and someone breaks into
your house, your alarm system won’t go off based on recognizing the intruder’s face,
but by the fact that they broke a window. So in a nutshell, it’s not recognizing the
molecule, but rather simply creating antibodies for things around mast cells degranulating. In support of this theory, Dr. Medzhitov and
co. began investigating potential cell damage caused by various allergens. For instance, when they injected mice with
an allergen found in honey-bee venom, PLA2, they found that their immune systems did not
initially respond at all to the PLA2 itself. It wasn’t until the PLA2 ripped open cell
membranes that the immune system kicked into gear producing IgE as a rapid response mechanism. And, as previously mentioned, other pathogens
in the area might potentially get implicated as the “house burglar,” with your immune
system creating the memory B cells to react to it later. Fascinatingly, no matter which side of the
why-we-get-allergies debate you’re on (or even if you think both ideas are partially
correct or both incorrect), one thing almost all researchers agree on is that allergy rates
are increasing. For instance, nearly 30% of adults and 40%
of children in the US are affected by some sort of allergy. Why? We’ve known for a long time that both genetics
and the environment play a part in getting allergies. Technology has also allowed us to create countless
never-before-seen synthetic chemicals. Their associated molecules could potentially
trigger any number of reactions by the immune system that our ancestors didn’t have to
worry about, perhaps being one factor in the increased allergy rates. Another potential factor is something known
as the hygiene hypothesis. Many scientists believe that with the promotion
of good hygiene taught throughout the industrialized world, which most definitely does have an
amazing number of significant benefits, there may also be a downside in that children aren’t
being exposed to as many pathogens that their immune systems can learn to respond to correctly,
or some even postulate potentially need to respond to develop the immune system properly. The idea in the latter case is that for most
of human evolution, the immune system developed being exposed to these pathogens as a matter
of course, and, similar to how we’ve evolved to need many types of microbes in the digestive
system to survive, the idea goes that the human immune system perhaps has evolved to
need to be exposed to certain things in order that it later correctly responds to introduced
pathogens, rather than triggering an allergic response to things it might be better off
ignoring. Thus the immune system later in life overreacts
to some things, or sometimes even reacts to parts of the body itself. Potential supporting evidence put forth in
support of this idea is the similar massive rise in not only allergy rates, but of various
auto-immune diseases. In both cases, there hasn’t been a corresponding
rise in allergy and auto-immune disease rates in individuals from underdeveloped countries
who get exposed to various pathogens more similar to our ancestors throughout history. On the flipside, children who live in urban
environments, and particularly those without siblings, have the highest allergy rates of
all. (Of course, that extra exposure to pathogens
comes with a cost in things like higher childhood mortality rates from said exposure and the
like. So even if the hygiene hypothesis is correct,
it would appear there’s something of a trade-off happening here.) As is now presumably abundantly clear, no
matter how we get allergies, the why is unfortunately still the topic of hot debate with little
in the way of concrete answers currently available. But whether you subscribe to the “recognition”
worm theory or the “alarm system” protecting your house theory, rest assured that IgE,
once thought to be mostly useless outside of its aid in expelling parasitic worms but
now thought by some to play a significant beneficial role in early recognition and reaction
to various pathogens, is the molecule responsible for all the madness. Along the lines of the idea that the immune
system needs to be exposed to certain things to properly develop, one proposed treatment
for certain allergies and auto-immune disorders is simply introducing parasitic worms to the
body, known as helminthic therapy. This therapy (usually) uses worms that have
limited negative long term impact on the human body and in some cases ones that will be naturally
expelled in due course. While research in this area is still very
much in the preliminary stages, the early results in some cases have been promising
enough to warrant continued research. For instance, as noted in one survey paper
on the subject, “In initial safety studies patients with Ulcerative colitis (UC) or Crohn’s
disease were given viable, embryonated T.suis eggs (TSO) and not only was the treatment
well tolerated but a significant disease remission was observed and although the beneficial effect
was temporary, repeated doses of TSO sustained this clinical improvement suggesting a promising
new therapy for IBD…” However, it goes on to note that after many
other studies looking at this therapy for various immune conditions, “…most of the
experimental data available suggest that once the allergic reaction is established, helminth
infections can do little to alter this, raising the inevitable question whether there is any
true benefit to gain from helminth therapy in already allergic individuals.”


100 thoughts on “Why Do We Get Allergies?

  1. I think the second theory is particularly correct but I think that genetics has something to do with it as allergies can be handed down. My mum is severely allergic to alcohol and I am allergic to some alcohol and I didn’t know that she was severely allergic until I was diagnosed

  2. I’ve found that not wearing shoes outside on grass and dirt helps my body learn what not to react to. An allergy researcher told me there are sensors on our feet that sense the environment and help the immune system figure out what is harmless. Sounds strange but it worked for me.

  3. I'm more interested in how the hell can you tell if you're allergic to something like…..dust? There's dust everywhere… so how the hell can you tell? what methods do the doctors use?

  4. I have allergies, I'm allergic to most things with fur & I get really bad hayfever.
    That's small fry compared to my eczema, my skin massively overreacts to allergens, sometimes I end up with raw flesh & other times my body produces extra layers of skin which really hurts. I end up in hospital every few years to be bandaged every night & I cannot tolerate any heat.
    I have to take immune suppressants to keep my allergies bearable, the side effects of the treatment leaves me drained of energy & means I catch every cough or sniffle, what is a small sniffle for one person will floor me for days. Also, because of the tablets I'm on I cannot go near someone who has shingles as it would most likely kill me.
    Life is such fun

  5. I say fuck all to antibacterial anything unless you work with sick, are old, or injured. Soap cleans your outside just fine, don't need all that other bullshit. I regularly let my cuts get infected so I can become stronger. I haven't been sick in over 8 years.

  6. How those cells do all this stuff? And atoms and stuff, it's almost like their alive like us just doing their own thing.

  7. it is illegial to bring any peanut or peanut oil product within a 1/2 mile of a public school, yet, my local grocery store sells fresh ground peanut butter in the health food aisle. How children entering the store are not dropping dead from anaphylactic shock, I dont understand, I mean so many children are sooo deathly allergic to anything that ever got anywhere near a peanut it must be banned in public schools . . . hmmmmmm

  8. I have tons of allergies, with my cat being sooo BAD it's off the charts according to my doctor. I've been scratched & had the skin around it swell up sooo fast that it doesn't have a chance to bleed. I also nearly died from holding a kitten as my airway swelled up sooo badly that I could hardly swallow.XD Stupid person who owned the cat told me, "Look at how much he loves you & besides, everyone thinks they're allergic, but they're not." XD I'm also allergic to several antibiotics & it's no fun feeling sick & then breaking out in hives after taking something that's supposed to make you feel better & get over being sick. XD And I played in the dirt as a kid & had various pets too, & while we never had a pet cat, I had friends who have them & I went over their house & just sneezed, wheezed & itched. XD

  9. so for less severe problems our immune systems just say screw it just kill the bastard and when it gets too dangerous for the immune system to deal with our immune systems just simply say PURGE THIS MONSTROSITY FROM OUR LORD

  10. I Would LOOOVE to have allergies rather then the thing i suffer from. Which is called vasomotoric rhinitis = non allergic rhinitis..its like allergic reaction but Without allergies.. There is no cure for it.. It can be caused any time of year, any time of day, BY ANYTHING, not only do i SNEEZE, , i can also vomit and feel ill for a few hrs. Its horrible and it ruins ny life. It always Come in the most bad of Times… Dates, working hours, going out With friends… Help me 🙁

  11. 1:06 , 1:17 … *hypothesis , *hypotheses … ?
    It wouldn't matter so much, but people need 'edumacating' in science … then psych and philosophy … then, we might not elect theocrats, kill ourselves so readily, etc …

  12. So basically we have allergies because our bodies are dumb and think they are parasitic worms and attacks for no reason

  13. I take opioids, for chronic pain from a broken back, and never suffer from alleries.
    So if everyone took opioids maybe they wouldn't suffer from allergies.
    Sure other problems come up but not allergies or colds.

  14. What about natural selection as a cause of increased rate of allergy sufferers? Improved hygiene also means that people who are vulnerable to developing allergies live longer than they would have in ages passed, and consequently, have more children. If there's a strong genetic component to allergies, then just the introduction of anti-histamines would have a dramatic affect in only a generation.

  15. Not a scientist per se, but using logic here – genetics clearly play the primary role in allergies and allergic reactions, and we know people can grow into and out of allergies. As stated in this video, white blood cells react to certain environmental triggers with the bodily response of “expelling” these targeted foreign invaders. That expelling makes sense, as typical allergens such as pollens, foods, or chemicals are larger than viruses and would illicit the same large-invader strategy of expelling instead of attacking. Also seems logical that on a genetic level, our bodies carry a running list of acceptable stimuli/molecules, and a list of unwelcome invaders.. Might even be a memory-based function similar to our olfactory sense of smell and storage of those sensations. But regardless, couldn’t it be as simple as a very minor genetic defect or alteration that allows certain typically-acceptable items to not be present on our bodily “accepted list”, and be attacked?. Such as basically damaged DNA or even inherited/developed DNA based on our parents and environment. Especially considering the prevalence of some seemingly strange allergic reactions such as to eating shellfish, being around cats and dogs, or the pollen of a particular flower.

    I understand the need to explain things from a context of evolution and natural selection, but our bodies do a lot of things that are flawed or not genetically ideal because of seemingly small genetic deviations or even areas that our genetics have yet to evolve and suitably adapt (for example, our bodies inability to target cancer cells even at a point of it metastasizing or intruding on basic bodily functions). Maybe the “answer” here is simply that, as the theory of evolution demonstrates, we are works IN PROGRESS and subject to fairly consistent changes over time, both (relatively) good and bad.

  16. I was never allergic to animals. Now it seems that if I pet a cat I'm subject to having a reaction. Some days out of nowhere I have allergic reactions to the air. It's nearly impossible to know when I'll react to them, and if I don't take medicine ASAP, I'll literally be completely non-functional for at least the next 6 hours.. I usually resort to carrying a t shirt around with me otherwise I will use 10 boxes of tissue

  17. I have a question. Where do curse words come from? The concept is pretty complex, so there must be some way to trace their origins. Do we know how words become considered curse words? Was there a first curse word? What language did they originate in and why?? Where do curse words come from???

  18. Why is it that people suffer from "fish" allergies and "nut" allergies when (A) according to Stephen J. Gould "There's no such thing as a fish.", and (B) most things we call nuts are not nuts.
    My mother has a nut allergy, but can (and regularly does) eat almonds and pistachios, for example.

  19. As a person who has a list or allergies that include the oil secreted by my hair and the salt from my tears/sweat, the only reason that people have allergies is because the world hates us.

  20. Is it possible to make your immune system forget about the allergy if you isolate yourself for a few years in a super clean air room?

  21. I never get sick haven't even gotten in a mild cold in about 2 years but I'm allergic to so much stuff thankfully no foods or medicine though

  22. Allergies to pollen, trees, dustmite, bee and wasp stiches almost killed me. Some acutely, some chronically. My mother had allergies too and my son also, although not as bad as I have them. It gets worse with age, even. Hurray for antihistamine pills and budesonide spray. Takes away 90% of the allergy for 20 hours a day. Saved my life, definetely. I had very dangerous inflammations in the upper face bone, jaw, lungs, eyes, etc (patially) caused by allergy. Immune therapy worked for four years, but the allergies came back. Now, I never forget my medicine and all is well.

  23. I'm allergic to shellfish. I have been so since the 1960's. Back in the 60's my parents thought I was trying to avoid eating healthy food that they had worked hard to afford (i.e. no belief that I was actually itching & thought I was trying to pull a ruse). These days, parents listen more to their kids are saying. Wonder how much this societal change over time (changes in standardly accepted "parenting" in developed countries) has changed the allergy count rate.

  24. Great video. I do wish the word “medicine” was not spoken as though there was no i after the d. After all, you don’t say “medcinal”!

  25. I have rheumatoid disease so my immune system goes haywire and attacks my body HOWEVER, i never get allergies.

  26. To all other allergy sufferers, find local honey, as the bees gather pollen from most of what you are allergic to and thru some miracle create a sweet out of it, it will give you a bit of an immunity to said pollen. It won't stop it but it does help a lot.
    And quit using anti-bacterial everything as your destroying the natural way your body creates a defense.

  27. We forgot 2 other major reason in the increase of allergies: globalization and survivability.
    200 years ago if you had a lethal peanut allergy, you just died. We tried to cure it with leeches. Just because we have a name for it now doesn't mean it hadnt existed.
    We have access to food from around the world all year round, but 150 years ago no one in Sweden had ever seen a banana, pineapple, or avocado. Ppl could have genetic level allergies and it never be a problem. We are exposed to so many more allergens that even our grandparent never had to deal with

  28. It's too bad he didn't cover why some allergies get weaker with repeated exposure while others get stronger. Most individuals who are allergic to pet dander, for example, will gain a tolerance over time if they live with a pet. Repeated exposure to latex, on the other hand, will often lead to worsening symptoms and even death in those who are allergic to it.

  29. It might have something to do with the trickery and games we play on our immune systems via vaccines, which are all about fooling you into having an overactive response to a false threat. So then it begins…

  30. Chase D didn't ask, he demanded! Rude.
    I'm allergic to aspirin, penicillin, nickel, coconut, shea butter and raspberry. All but the first two are skin contact only.

  31. And so, it comes down to move or suffer. I hate sage brush, blooms year round, has so many, many varieties, and makes me miserable. Give me seasonal allergies any day, those I can cope with. We won't talk about the allergy to liquor, that one just makes me sad.

  32. I have a nephew who will have an anaphylactic reaction if he's exposed to anything that contains cashews or pistachios. I'll take my pollen and cat allergy over that any day.

  33. I observed a child about three years old waiting in line at a Chinese takeout restaurant. He had a jaw-breaker type candy in his mouth, that fell out onto the filthy floor of the restaurant. His dad picked it up and gave it back to him and he continued to suck on it! Now I would assume this kind of behavior happens all the time in this family, and this kid looked healthy as could be. I bet he doesn’t have many allergies throughout his lifetime.

  34. Love the vid' Simon et al…
    AND I'm going for an unpopular camp. Other than the odd occasions when the damn things get completely out of control, I rather enjoy my allergies… The odd sneeze is refreshing like a tingling aeration of my brain, and mixed occasionally with a thoroughly horrible obscenity at the top of my voice, it tends to drive people the hell away… It's simply the FASTEST and MOST EFFECTIVE way to get a seat on any public transit EVER.
    …AND nobody, I mean NOBODY wants to interfere with you, once you've snorted loudly and dragged your nose over your sleeve. ;o)

  35. I used to get grass allergies as a kid, but now as an adult it makes me sneeze and that's about it. When I traveled to Australia and worked on a farm, I rode in an ATV which ripped through an unmowed sheep paddock which resulted in the worst reaction I've ever experienced. I was hoarse and my breathing was labored. My immune system had not been exposed to that type of grass before, so it went crazy trying to fight it.

    If you're travelling abroad and have had hay fever in the past, use antihistamines!

  36. I'm allergic to mosquitoes. Not just being bitten by them, their actual presence. If there are any mosquitoes in my vicinity (eg same room) my eyes water, my nose and skin get itchy.
    I'm also allergic to scented products, cigarette smoke, wool, and many other things.

  37. So "synthetic chemicals" causing allergies is a thing… My boss was talking about McDonald's and such causing increasing numbers of allergies in people and I was kinda doubtful, but I guess that's somewhat maybe true… I still think he was going a bit far by complaining about how you can't have peanuts in schools these days because people now have peanut allergies… Like, I'm pretty sure peanut allergies are not a new thing, just maybe more common though regardless I'd support banning peanuts in schools since the benefits don't feel like they outweigh the cost… He also argued that cancer was a new thing which was ridiculous since it's more just we now have an understanding of what cancer is whereas before I think a lot of the time they likely did not know and probably considered it just vague natural causes…

  38. I got camplyobacta poisoning and was never the same then during a stressful time after that I got chronic urticaria angiodema and dermagraphism. Basically my mast cells now are being attack by histamene. I still feel somehow it was related to the parasite infection but who knows, now 2 anti-histamines a day for the rest of my life. Interesting video, never heard the worm theory before.

  39. I wish I could explain my cat allergy that I've developed recently with genetics and the exposure theory, but neither of my parents (or grandparents) ever had cat allergies, I was raised with cats, dogs, and ferrets and only now as I'm nearing 30 have I developed a reaction to my parent's cats. The same is happening with my sister, and my brother who always had allergy to various things has gotten more severe.

  40. Interesting thing. There is this man in Iowa that is some kind of neurologist but studies a kind that isn't common today. He helps people with migraines and back problems. But the confusing thing is that he gets rid of some peoples allergies. He knows which he can help with and what he can't. But he always brings in the thing that they are allergic to in a bottle and helps them someway through that. At least 12 people from my church have lost allergies that were deathly by going to him. But some kinds he can't help with. Dad says that he knew someone a while back that could do a similar thing. Is this some kind of older medicine practice that has gotten replaced by modern medicines that don't actually do much? I'm very confused.

  41. I grew up with cats until I was 8, we then had a dog, but when we moved and got more cats I discovered I was alergic to them, despite not having any alergy symptoms in early childhood. The only thing I can think of that changed was me going through puberty, and that somehow changing my immune system.

  42. I hear that the blue whale is the largest animal at present and probably of all time. I am not surprised at the "largest animal at present," such a thing can be documented. The "largest animal …….of all time" seems a wild statement. The explanation must be interesting, perhaps worthy of one of your videos.

  43. I have allergies. Some I have had my whole life. One,I developed last year. I wasn't allergic to the item in the past but now I am. The reaction my body had was horrible. Now I have to give up a food I used to enjoy. I was really surprised when it happened. I didn't think that it was possible for me to become allergic to an item later in life. It taught me it can happen to anyone. Live and learn I guess.

  44. I have allergies to pollen, cat hair and certain trees. Pretty much bothers me year round.
    The problem is that I'm also allergic to antihistamines. Fun.
    (And no I'm not rich, despite what some of the comments here would like to imply.)

  45. Personally I think that, as well as some of the reasons stated in this video, the reason allergies are more common is because of modern medicine. When an allergic reaction such as one to peanuts or a wasp sting may kill someone in the past, we have effective ways of dealing with them in the present. We are basically denying Darwin's principle and so while a person would have died in the past, they would survive today. Another thing is the decrease of infant mortality rates. We naturally just have more babies surviving when in the past they may have had an allergic reaction or died from some other cause before their allergy was discovered. It may not necessarily be that we do have higher allergy rates (although I think we do), just that we are more knowledgeable about them and know how to deal with them as well as detect and catalog them.

  46. I really wish you would stop inserting ads into your videos. I purchased YouTube red to get rid of ads. So you started putting ads into your ads. I DONT CARE IM NOT BUYING YOUR SHIT FUCK OFF QUIT BOTHERING ME

  47. I think I'm going to leave this channel. I used to love this but lately, it's been tidbits of information broken up by ads. I can't stand them! It ruins the flow of the information and show.

  48. I think that getting exposed to stuff at a young age actually helped me out. When I was a baby, I would eat dirt. My brother did so as well. Neither of us get sick too often, nor do we have too many allergies other than to goldenrod pollen, oak pollen and poison ivy. Our dad never grew up with cat and has a slight allergy to cat dandrift while no one else in the family has such an allergy.

  49. I used to get hayfever and have fairly nasty dust and animal hair allergies. Now, as long as I keep my intake of omega 6 down (e.g. mostly avoiding things containing sunflower oil or peanut oil) then my allergies stay inert 😮

  50. I have a hyperactive immune system. I also have a hyperactive metabolism. This means getting me sick is very difficult. During my life, I purposely made myself sick so my immune system would evolve and adapt. THAT is why people are getting sick so easily AND having so many allergies. You stupid humans have stagnated your immune systems by making everything around you sterile. The body NEEDS to get infected to encourage evolution and adaptation. So point of fact, you humans made yourselves weak to everything else. It's entirely your fault.

  51. I'm allergic to pollen and a drug called Reglan. With pollen my nose drips and I sneeze a lot. I can also get hives if my immune system goes into overdrive. With Reglan I nearly died when the drug caused me to have a severe seizure and I nearly went into heart failure. I have to take lots of medicine to keep my allergy to pollen in check and doctors and phramarcies have to be warned about how I react to Reglan.

  52. My mums years ago developed a cucumber allergy and in the last ew years has got a gluten allergy Whitchurch my grandma also has. Add to that I became allergic to corn in the last decade.

  53. THose were pictures of rats, not mice! the second picture was a very young rat. they are both cute of course, I just thought this channel may want to check in the future, so as to be more accurate.

  54. Small criticism here. I like the subjects you address on your channel. But… I have difficulty understanding you. You speak very quickly and with a very heavy accent. As a Texan it's challenging to understand the words that are coming out of your mouth. So if possible, could you either change your accent, or possibly slow down just a bit. I hate to nitpick like I said I love your channel and your subjects. Keep up the good work!

  55. Well, I grew up in an urban environment without siblings and I have no allergies that I know of. I guess I'm really lucky. I remember seeing something in a Thoughty2 video about allergies that children who were raised in rural areas, and consequently inhaled dusty air, were shown to develop fewer allergies. This dusty air is apparently so effective at preventing allergies that some scientists want to have it put into gas masks for urban children to breathe as a sort of vaccine.

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